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Magnesium in menopause: sleep, hot flashes, bones and safety

Magnesium is an essential mineral found in nuts, seeds, beans and whole grains. A large trial found it did not help hot flashes, and evidence for sleep is weak.

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See a doctor if you have kidney disease, ongoing muscle cramps, irregular heartbeat or severe diarrhea, or if you take medicines for the heart, bones or stomach acid.

What it is

Magnesium is a mineral the body needs for more than 300 chemical reactions. It supports muscles, nerves, energy, blood sugar control and blood pressure. About half of the body's magnesium is stored in bone.1

Good food sources include leafy greens, beans, nuts, seeds and whole grains. Supplements come in several forms, such as citrate, oxide and chloride. Some forms may be absorbed better than others, but these studies were small.1

Deficiency is uncommon in healthy people. It is more likely in older adults and people with type 2 diabetes, gut conditions or heavy alcohol use.1

What the research shows

Hot flashes. A US trial gave magnesium oxide or placebo to 289 postmenopausal women with a history of breast cancer. Hot flash scores were similar in all groups, and the authors said results did not support its use.2 The Menopause Society does not recommend supplements in general for hot flashes.4

Sleep. A 2021 review found 3 small trials with 151 older adults. Magnesium helped people fall asleep about 17 minutes faster than placebo. The evidence was low to very low quality.3

Headaches. Three of four small trials found magnesium modestly reduced how often migraines happened. US headache experts say it is probably effective for prevention, under a doctor's supervision.1

Bones. Some studies link higher magnesium intake to higher bone density. Evidence that supplements help bone is limited, and more research is needed.1

Blood pressure. Supplements may lower blood pressure slightly. One analysis of 22 studies with 1,173 adults found drops of a few points.1

Safety and who should be careful

Magnesium from food is safe for healthy people because the kidneys remove any extra. High doses from supplements often cause diarrhea, nausea and cramps.1

People with kidney disease are at higher risk of magnesium building up. Very high intakes, usually from laxatives or antacids, have caused serious harm, including heart rhythm problems.1

Magnesium can interact with several medicines. It can reduce absorption of some osteoporosis drugs (bisphosphonates) and some antibiotics. Some water pills and long-term stomach acid medicines (PPIs) can change magnesium levels.1

A doctor or pharmacist can check whether it interacts with any medicines or other supplements you take.

How it is available

Magnesium supplements are sold over the counter in most countries. It is also found in some antacids and laxatives.1 Many people can get enough magnesium from a varied diet.

The bottom line

Getting enough magnesium from food supports general health. A varied diet with greens, beans, nuts and whole grains is the simplest way to do this.1

The best trial so far found magnesium did not help hot flashes.2 Evidence for sleep is weak and comes from small, older-adult studies.3

If sleep is a problem, CBT for insomnia has stronger evidence. If you want to try magnesium, check with a doctor or pharmacist first, especially if you take other medicines or have kidney problems.1

What it is used for: evidence rated

OptionEvidenceWhat the research shows
Headaches (migraine)Some evidenceThree of four small trials found fewer migraines, and headache experts rate it probably effective.1
Hot flashesWeak evidenceA trial of 289 women with past breast cancer found no difference from placebo.2
Sleep problemsWeak evidenceThree small trials in older adults showed a modest effect on falling asleep; evidence was low quality.3
Bone lossWeak evidenceHigher intake is linked to higher bone density, but supplement trials are few and small.1

Ratings explained: how we rate. Always talk to a doctor or pharmacist before starting a medicine or supplement.

Related

Sources

  1. Magnesium: Fact Sheet for Health Professionals, NIH Office of Dietary Supplements
  2. NCCTG N10C2 (Alliance): placebo-controlled trial of magnesium oxide for hot flashes, Menopause (2015)
  3. Oral magnesium supplementation for insomnia in older adults: systematic review and meta-analysis, BMC Complementary Medicine and Therapies (2021)
  4. The 2023 nonhormone therapy position statement of The North American Menopause Society, Menopause (2023)